Synthèse, caractérisation et l’activité anti-tumorale d’un complexe organo-étain carboxylique

Le probleme du cancer constitue a l’echelle planetaire une preoccupation de sante publique. Il a ete longtemps sous-estime par les structures sanitaires en Africaines a cause de la pression exercee par les maladies transmissibles et carentielles sur les services de sante. Son influence negative peut etre pourtant reduite grâce au programme de lutte contre le cancer mis en place. Ce programme necessite la mobilisation des ressources humaines, materielles, intellectuelles, services de sante, l’associations des malades de cancer. Dans le souci de remedier a ce probleme de sante publique, un complexe d’organo-etain carboxylique de formule [(Bu)2Sn]4(L1)2O3(Br)2] a ete synthetise. La molecule obtenue a ete caracterisee par les methodes d’analyses elementaires, spectroscopiques (RMN 1H et FT-IR) et par la technique de diffraction aux rayons X. Il a ete constate que cette molecule presente un fragment Sn4O2Br2 unit dont l’interaction Sn…O, conduit a la formation d’une chaine supramoleculaire. Son activite anti-tumorale sur les differentes cellules a presentee des resultats significatifs.Mots cles : Synthese, complexe d’organo-etain carboxylique, caracterisation, chaine supramoleculaire, anti-tumorale. English Title: Synthesis, characterization and anti-tumor activity of complex organotin carboxylate The cancer problem is a global public health concern. It has long been underestimated by health structures in Africa because of the pressure exerted by communicable and deficient diseases on health services. Its negative influence can however be reduced thanks to the cancer control program put in place. This program requires the mobilization of human, material, intellectual resources, health services, associations of cancer patient. In order to remedy this public health problem, an organotin carboxylic complex of formula [(Bu)2Sn]4L1)2O3(Br)2] has been synthesized. The molecule obtained was characterized by elementary, spectroscopic analysis methods (1 H NMR and FT-IR) and by the X-ray diffraction technique. It was found that this molecule has a Sn4O2Br2 unit fragment whose interaction Sn…O leads to the formation of a supramolecular chain. Its anti-tumor activity on the various cells has presented significant results.Keywords: Synthesis, organotin carboxylic complex, characterization, supramolecular chain, anti-tumor.