Tuning the Organelle Specificity and Cytotoxicity of Iridium(III) Photosensitisers for Enhanced Phototheranostic Applications

Luminescent cyclometallated iridium(III) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient imaging reagents and photosensitisers that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.