Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)

Abstract Two new dammarane triterpenoids, aglinone ( 1 ) and aglinin E (20 S ,24 S -epoxy-25-hydroxy-1-en-dammarene) ( 2 ) along with three known compounds, 3-epiocotillol ( 3 ), aglinin A ( 4 ), and eichlerianic acid ( 5 ), were isolated from the bark of Aglaia smithii . The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1 , 2 , 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC 50 values of 21, 42, 34, and 11 μg/mL, respectively.