Small-Molecule Antagonists of Bcl-2 Family Proteins

Abstract The Bcl-2 family of proteins is central to regulating apoptosis, and selective inhibition of Bcl-2 family proteins has been shown to be a promising strategy for the treatment of cancer. Several small-molecule Bcl-2 family inhibitors are currently progressing through clinical trials, and there is continuing interest in this family of targets throughout the pharmaceutical industry. This review surveys the small-molecule Bcl-2 family inhibitors reported in the literature and discusses the various strategies employed to discover them.