CHEMICAL MODIFICATION OF THE GE 2270A MACROCYCLE (MDL 62,879)
1996
Abstract Controlled acid hydrolysis of compound 2 resulted in the selective opening of the macrocycle while in basic condition a retro-aldol reaction occurred at the level of phenylserine thiazole. Compound 2 can be easily prepared from the natural antibiotic MDL 62,879. All the compounds prepared resulted less active than MDL 62,879.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
7
References
11
Citations
NaN
KQI