Novel Series of Coumarinyl Substituted-thiazolidin-2,4-dione Analogs as Anticancer Agents: Design, Synthesis, Spectral Studies and Cytotoxicity Evaluation
2015
In this research work, a series of eighteen novel coumarinyl substituted thiazolidin-2,4-dione analogs
(4a-4r) have been designed by molecular hybridization approach, synthesized and their structures were established
on the basis of FTIR, 1H NMR, 13C NMR and elemental (CHN) analysis. These title compounds were screened for
their cytotoxicity using MTT assay methodology against five different mammalian cancer cell lines viz. hormone
dependant breast adenocarcinoma (MCF7), cervical carcinoma (HeLa), colorectal carcinoma (HT29), lung cancer (A549) and prostate
adeno carcinoma (PC3). The cytotoxicity screening studies revealed that MCF-7, HeLa and A549 cancer cell lines were sensitive to all
the tested compounds. Though the compounds showed varying degrees of cytotoxicity in the tested cell lines, most significant effect was
observed for compounds 4i (1.06, 2.4 and 3.06 µM) and 4o (0.95, 3.2 and 2.38 μM) against MCF7, HeLa and A549 cell lines
respectively. In conclusion, the anticancer results of these promising leads strongly encouraged us for additional lead optimization with
the aim of developing more potential anticancer agents.
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