Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

Kenneth M. Meyers,Nick Kim,José L. Méndez-Andino,X. Eric Hu,Rashid Naeem Mumin,Sean Rees Klopfenstein,John August Wos,Maria C. Mitchell,Jennifer L. Paris,David C. Ackley,Jerry K. Holbert,Scott W. Mittelstadt,Ofer Reizes

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

2007

Kenneth M. Meyers
Nick Kim
José L. Méndez-Andino
X. Eric Hu
Rashid Naeem Mumin
Sean Rees Klopfenstein
John August Wos
Maria C. Mitchell
Jennifer L. Paris
David C. Ackley
Jerry K. Holbert
Scott W. Mittelstadt
Ofer Reizes

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.

Keywords:

hERG
Biochemistry
Organic chemistry
Biphenyl
Carboxamide
Chemistry
Chemical synthesis
biphenyl derivatives
Selectivity
nutritional status
Stereochemistry

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