A novel probe for imaging amyloid-β : Synthesis of F-18 labelled BF-108, an Acridine Orange analog

The synthesis of 3-(2-[18F]fluoroethyl)ethylamino-6-diethylaminoacridine ([18F]BF-108), a potential positron-labelled probe for imaging amyloid-β is described. The precursor tosylate derivative was fluorinated with [18F]KF/ Kryptofix 222 in acetonitrile, and the crude product was purified by semi-preparative HPLC to give the radiolabelled BF-108. The radiochemical purity was >95% and the maximum specific activity was 33.9 TBq/mmol at the end of the synthesis (EOS). The synthesis time was 130 min from the end of bombardment (EOB). Copyright © 2003 John Wiley & Sons, Ltd.