Procedure for the preparation of 4-methylamine-4-phenylpiperidine.

2002 
Process for the preparation of a 4-alkoxycarbonylamino-1-benzyl-4-phenylpiperidine of formula (I) (See formula) in which Alk represents an alkyl of 1 to 3 carbon atoms, characterized in that the 1-benzyl is hydrolyzed in amide. 4-Cyano-4-phenylpiperidine of formula (II) (See formula) in acidic medium and the 1-benzyl-4-phenyl-4-piperidinecarboxamide thus obtained from formula (III) (See formula) is treated with bromine in the presence of an alkali metal alcoholate of formula (IV) Alk-OM (IV) in which Alk is a (C1-C3) alkyl and M is an alkali metal.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    0
    References
    0
    Citations
    NaN
    KQI
    []