Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Giovanni Germano,Simona Lamba,Giuseppe Rospo,Ludovic Barault,Alessandro Magri,Federica Maione,Mariangela Russo,Giovanni Crisafulli,Alice Bartolini,Giulia Lerda,Giulia Siravegna,Benedetta Mussolin,Roberta Frapolli,Monica Montone,Federica Morano,Filippo de Braud,Nabil Amirouchene Angelozzi,Silvia Marsoni,Maurizio D’Incalci,Armando Orlandi,Enrico Giraudo,Andrea Sartore-Bianchi,Salvatore Siena,Filippo Pietrantonio,Federica Di Nicolantonio,Alberto Bardelli

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

2017

The inactivation of DNA mismatch repair in cancer cells produces dynamic mutational profiles and generates neoantigens, which result in improved immune surveillance against these cells.

Keywords:

Cancer cell
Cancer
Immune system
DNA mismatch repair
Genetics
Cancer research
DNA repair
Biology
MLH1
Transplantation
Immunotherapy
Clone (cell biology)

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