Palladium-Catalyzed Nitrile-Assisted C(sp3)–Cl Bond Formation for Synthesis of Dichlorides
2019
A palladium-catalyzed coupling procedure of alkenes with alkynylnitriles has been demonstrated for the synthesis of dichlorides. The reaction is the first example of nitrile-assisted C(sp3)–Cl formation promoted by coordination of a cyano group with an alkylpalladium(II) complex. The construction of a five-membered cycle intermediate successfully inhibits the β-hydride abstraction, resulting in direct C–Cl bond reductive elimination of alkylpalladium(II) chloride.
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