Advances in genetic research and treatment of resistant ovary syndrome

At present, the research on resistant ovary syndrome (ROS) remains inconclusive. Due to its low incidence, there are many case reports but no large sample investigation, which have focused on the pre-gonadotropin receptor levels and partially on the receptor levels. The possible mechanism of ROS is that gonadotropin cannot effectively act on the follicles, so that the follicles cannot develop normally and stagnate in a resting state. ROS is likely involved in mutations in the gene of FSH receptor or its β-subunit, autoimmune processes, and transient down-regulation of gonadotropin receptors on vascular cells. ROS-related gene mutations are currently a hot topic, but due to the specificity of ROS cases it is difficult to continuously discover new gene mutations. This article reviews and analyzes the relevant literature, and summarizes the genetic etiology and the latest treatment strategies of this disease, in order to provide some reference for clinical studies. Key words: Ovarian insensitivity syndrome; Genetics; Gene mutation; Gene therapy