Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors

David Lindsey Soper,Justin Sheville,Steven V. O’Neil,Yili Wang,Michael C. Laufersweiler,Kofi A. Oppong,John August Wos,Christopher D. Ellis,Mark William Baize,Jack J. Chen,Amy N. Fancher,Wei Lu,Maureen K. Suchanek,Richard L. Wang,William P. Schwecke,Charles A. Cruze,Maria Buchalova,Marina Belkin,Fred Christian Wireko,Amanda Ritter,Biswanath De,Difei Wang,Thomas P. Demuth

Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors

2006

Abstract An 8,5-fused bicyclic peptidomimetic ring system generated by a stereoselective ring metathesis reaction was elaborated into potent inhibitors of interleukin-1β converting enzyme (ICE, caspase-1). Multiple compounds were found that exhibited ICE IC 50 values 50 values

Keywords:

Salt metathesis reaction
Chemical synthesis
Organic chemistry
Metathesis
Peptidomimetic
Ice Ic
Bicyclic molecule
Biochemistry
Acetal
Stereochemistry
Chemistry
Enzyme inhibitor
Prodrug
Stereoselectivity

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