Interaction of human blood platelet aggregation inhibitors with phospholipid films

Abstract A series of carbamoylpiperidines and related entities, a class of compounds only recently identified by the authors as potent human blood platelet aggregation inhibitors, showed correspondingly strong levels of “specific” interaction, in monomolecular film systems, with some phospholipids viewed as prototypes of actual platelet plasma membrane constituents. The data strongly corroborate our previously articulated view that our compounds possess appropriate hydrophobic character to penetrate the lipid bilayer of the platelet plasma membrane, subsequently are capable of generating sufficient quantities of their cationic species to counteract massively stimulus-induced mobilization of Ca ++ ions, and thereby restrain or void Ca ++ -dependent phospholipase activity.