Role of expression of p53 and Ki67 in the progression of Wilms tumor; correlation with survival

Background: Wilms tumor (WT) is the most frequent renal tumor of childhood and is a highly responsive tumor to chemotherapy. P53 and ki67 are two of the most important markers that have been evaluated in many cancers. The role of p53 in the pathogenesis and progression of WT is only partly understood. Over the past decade, the importance of Ki-67 in the prognosis of breast cancer has been widely studied. On the other hand, fewer studies are available for this in WT. Aim: To study the possible role of p53 and ki67 in the progression and outcome of Wilms tumor cases. Methods: Immunohistochemical (IHC) staining for p53 and ki67 were done and correlated with clinicopathological data of Wilms tumor cases. Results: There was a positive correlation between p53 and ki67 expression and unfavorable histology, higher tumor stage, shorter disease-free survival (DFS) and overall survival (OS). Conclusion: Ki67 and p53 expression was positively correlated with aggressive behavior of Wilms tumor