Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents
2015
The synthesis of a variety of phenyl- and indeno-1,5-naphthyridine derivatives as new substrates
with anticancer activity is described. Several of the prepared products were addressed to in vitro anticancer
screening which indicated that some of them exhibited inhibitory effect of Top1 and antiproliferative activity
against human colon cancer cells (COLO 205).
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