1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity.

Abstract A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives ( 15 – 35 ) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22 , 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity.