Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy

TAK1 is a key mediator of proinflammatory signals. In this issue of Developmental Cell , Naito et al. (2019) report that TAK1 loss from endothelial cells in adult mice results in intestinal and hepatic vascular destruction due to TNF-induced death of endothelial cells. Additionally, endothelial TAK1 deletion reduces tumor burden.