Total synthesis of (±)-erythrodiene and (±)-spirojatamol

Abstract A unique synthetic strategy toward (±)-erythrodiene and (±)-spirojatamol was achieved from cyclobutone and isobutyraldehyde through an 11-step synthetic route. During the work, a tandem Castro-Stephens coupling/ 1, 3-acyloxy shift/ cyclization/ semipinacol rearrangement sequence, which was developed recently by the same group, was used as the key step to build the crucial spirocyclic intermediate 5b.