Tumor Microenvironment-Activatable Nanoreactor Based on Polyprodrug for Multimodal Imaging-Medicated Enhanced Cancer Chemo/Phototherapy

Anticancer nanomedicine-based multimodal imaging and synergistic therapy hold great promise in cancer diagnosis and therapy owing to its abilities to improve therapeutic efficiency and reduce unnecessary side-effects, producing a promising clinical prospects. Herein, we integrated chemotherapeutic drug camptothecin (CPT) and near infrared (NIR) absorbing new indocyanine green (IR820) into a single system by charge interaction, and got a tumor microenvironment (TME)-activatable PCPTSS/IR820 nanoreactor to perform thermal/fluorescence/photoacoustic imaging-guided chemotherapy and photothermal therapy (PTT) simultaneously. Specifically, the generated PCPTSS/IR820 showed excellent therapeutic agent loading content and size stability, and the trials in vitro and in vivo suggested that the smart PCPTSS/IR820 could deeply permeate into tumor tissue due to its suitable micellar size. Upon near infrared laser irradiation, the nanoreactor further produced a terrific synergism of chemo-photo treatment for cancer the...