Synthesis and biological activity of 2-thiono-[1H]-5-spirocyclohexylimidazo[4,3-b]quinazolone and 8-azaquinazolone derivatives.
2001
The reaction of 5-spirocyclohexylimidazole-2,4-dithion with one and two mole equivalent of b-aminocarboxylic acid derivatives (2a-b and 5) to give new heterocyclic systems of synthetic and potential biological interest viz. compounds (3a-b, 4a-b, 6 and 7). The structures of the products have established by chemical and spectroscopic evidence. The antimicrobial activity of the synthesized compounds was tested against 10 bacterial and yeast strains.
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