NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation.

Cui-Zan Cai,Chuanbin Yang,Xu-Xu Zhuang,Ning-Ning Yuan,Ming-Yue Wu,Jieqiong Tan,Ju-Xian Song,King-Ho Cheung,Huanxing Su,Yitao Wang,Beisha Tang,Christian Behrends,Siva Sundara Kumar Durairajan,Zhenyu Yue,Min Li,Jia-Hong Lu

NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation.

2020

Cui-Zan Cai
Chuanbin Yang
Xu-Xu Zhuang
Ning-Ning Yuan
Ming-Yue Wu
Jieqiong Tan
Ju-Xian Song
King-Ho Cheung
Huanxing Su
Yitao Wang
Beisha Tang
Christian Behrends
Siva Sundara Kumar Durairajan
Zhenyu Yue
Min Li
Jia-Hong Lu

NRBF2 is a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex. Our previous study has revealed its role in regulating ATG14-associated PtdIns3K activity for autophagosome i...

Keywords:

Biochemistry
Effector
Cell biology
Autophagosome
class iii
Phosphatidylinositol
Autophagosome maturation
Biology
Autophagy

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