Preliminary Evaluation on Cerebral Small Vascular Disease with Cerebral Arerio-venous Pulse Wave Time

In order to investigate the relationship between cerebral arerio-venous pulse wave time (CAV-PWT) and cerebral small vascular disease, this paper deals with 132 patients with cerebral small vascular disease and 115 sex-andage-matched control subjects. The pulse wave of terminal internal carotid artery and basal vein were simultaneously monitored by TCD(Transcranial Doppler), and the CAV-PWTs were calculated. The difference between the two groups’ CAVPWT, and the relationships between CAV-PWT and demographic data and risk factors were analyzed. In the process of research, we got the following results. Firstly the normal range of CAV-PWT was .1389±.02429s in normal people, while there were no significant statistical differences in the youth, middle-aged and elderly group. The CAV-PWT in middle-age group of lacunar cerebral infarction group and cerebral hemorrhage group, mixed group were significantly shortened than that in the control group, whereas there were no significant statistical differences in the elderly group. Secondly, the risk of cerebral arteriosclerosis with shortened CAV-PWT was 3.396 times than that of the normal people. And logistic regression analysis showed that age, CAV - PWT, hyperlipidemia, cerebral arteriosclerosis were more sensitive risk factors of lacunar cerebral infarction.( P<0.05). At last, the CAV-PWT in the moderate cerebral arteriosclerosis group were significantly shortened than that in the mild group . The results show that the CAV-PWT of patients with cerebral small vascular disease was shortened significantly, which might be associated with cerebral arteriolosclerosis