Amino acids phenylacetic substituted derivatives thereof, their preparation and their use as inhibitors of cyclooxygenase 2 (cox-2).

A compound of formula (I) ** ** see formula wherein R is located at position 5 and is C1-C4 alkyl, (C3-C6), hydroxy, halo, methoxy, ethoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is optionally substituted quinolinyl; the optional substituents are selected from C1-C4 alkyl, methoxy, ethoxy, halo and trifluoromethyl alkyl; or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable ester thereof selected from the group consisting of C1-C4 alkyl, carboxy-C1-C4 alkyl and nitrooxy- or nitrosooxy-C1-C4 alkyl.