Haemato-biochemical effects of dimethoate induced sub-acute toxicity in rabbits (Oryctolagus cuniculus)

The present study was aimed to assess the subacute toxic effects of dimethoate using rabbits as mammalian model. TAFGOR (containing 35.5% dimethoate) was admistered @ 36 mg dimethoate/kg body weight per day orally for 14 days. The clinical signs of toxicity were dullness, anorexia, dehydration, excessive salivation, muscle contractions, staggering gait and loss of weight. Blood samples were collected at day 0, 7 and day 15 for hematological and biochemical analysis. The intoxicated rabbits showed a significant increase in mean monocyte, eosinophil count (P