RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual healthproducts

Abstract In this work, a highly sensitive and selective biomimetic electrochemical sensor for Sildenafil in herbal sexual health products was prepared. Reduced graphene oxide (RGO), a novel highly conductive material was used to modify glassy carbon electrode (GCE) through layer-by-layer (LBL) self-assembly. The conductive molecularly imprinted films were constructed on the functional electrode surface using Sildenafil as template molecules, p -phenylenediamine ( p -PD) as functional monomers. The obtained molecularly imprinted electrochemical sensor (MIES) was successfully used to detect Sildenafil in herbal sexual health products. The limit of detection (LOD) was 6.2 nmol L −1 . The recoveries for the spiked Sildenafil contents were in the range of 92.34–97.71% with the RSD