Optimized pre-clinical grade production of two novel lentiviral vector pseudotypes for lung gene delivery

María Carla Rosales Gerpe,Laura P. van Lieshout,Jakob M. Domm,Jacob P. van Vloten,Jodre Datu,Joelle C. Ingrao,Darrick L. Yu,Jondavid de Jong,Theo J. Moraes,Peter J. Krell,Byram W. Bridle,Sarah K. Wootton

Optimized pre-clinical grade production of two novel lentiviral vector pseudotypes for lung gene delivery

2020

María Carla Rosales Gerpe
Laura P. van Lieshout
Jakob M. Domm
Jacob P. van Vloten
Jodre Datu
Joelle C. Ingrao
Darrick L. Yu
Jondavid de Jong
Theo J. Moraes
Peter J. Krell
Byram W. Bridle
Sarah K. Wootton

Lung gene therapy requires efficient transduction of slow-replicating epithelia and stable expression of delivered transgenes in the respiratory tract. Lentiviral vectors (LV) have the ideal coding...

Keywords:

Transgene
Viral vector
Virology
Respiratory tract
Lung
Genetic enhancement
Gene delivery
Biology
Transduction (genetics)
clinical grade

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations