Antigen Society #16 Report (Cw1, Cw3, Cw9, Cwl0, Cw11)

HLA-Cw1 and HLA-Cw3 were first described in the Fourth and the Fifth International Histocompatibility Workshops, respectively (1,2). The three subtypic factors of Cw3, namely Cw3.1, Cw3.2, and Cw3.3, were demonstrated in the Ninth International Histocompatibility Workshop (3). The expression of Cw1 and Cw3 on the same haplotype in Orientals was observed by Payne et al. in 1975 (4) and was later found to be strongly associated with Bw46. CwB had been proposed as a new C locus antigen for this Cw1-Cw3 co-segregating phenotype in the Second Asia and Oceania Histocompatibility (AOH) Workshop (5). However, CX46 was more recently used to designate this C locus antigen in the Third AOH Workshop (6). In the present Workshop, the new assignment of HLA specificities is given by the WHO nomenclature committee (7). This included antigens in C locus, i.e., Cw9 (Cw3. 1), Cw10 (Cw3.2), and Cw11 (CX46, Cw1+3, Cw1X3, C-Bangkok, CSH1).