온라인 액체크로마토그래프-고분해능 질량분석기를 이용한 하천수 중극성유기화합물질의 동시분석

We categorized 78 hazardous polar organic compounds containing pharmaceuticals and personal care products (PPCPs), pesticides, and industrial chemicals potentially discharged into a river. We developed an automated online liquid chromatography-high resolution mass spectrometric (LC-HRMS) method for the rapid simultaneous determination of 78 polar organic compounds. The method was validated in terms of calibration curve linearity, limit of detection (LOD), limit of quantitation (LOQ), accuracy, and precision. The LOD and LOQ were in the range of 0.03-47.6 ng/L and 0.1-151 ‌ﾠng/L respectively. Good accuracy and precision were also obtained. The con‌ﾠcentrations of 78 compounds were determined in river water samples, and 60 compounds were detected. Caffeine was the most frequently observed PPCPs in river water.