INFLAMMATORY REACTIONS INDUCED BY VARIOUS CALCIUM PYROPHOSPHATE CRYSTALS

Abstract Various inflammatory reactions can be induced by different crystals responsible for various arthropathies. The aim of this work was to study modifications induced in the rat, locally and at distance, by intrapleural injection of 3 forms of pyrophosphate crystals (CaPP dihydrated monoclinic (M), CaPP dihydrated triclinic (T) and CaPP anhydrous (β)). The data presented here show that the structure of irritants plays a decisive role in the kinetics of inflammatory reactions from a local and systemic point of view. CaPP crystals / pleurisies / polymorphonuclear / macrophages.