Optogenetic control with a photocleavable protein, PhoCl

Wei Zhang,Alexander W. Lohman,Yevgeniya Zhuravlova,Xiaocen Lu,Matthew D. Wiens,Hiofan Hoi,Sine Yaganoglu,Manuel A. Mohr,Elena N. Kitova,John S. Klassen,Periklis Pantazis,Roger J. Thompson,Robert E. Campbell

Optogenetic control with a photocleavable protein, PhoCl

2017

Wei Zhang
Alexander W. Lohman
Yevgeniya Zhuravlova
Xiaocen Lu
Matthew D. Wiens
Hiofan Hoi
Sine Yaganoglu
Manuel A. Mohr
Elena N. Kitova
John S. Klassen
Periklis Pantazis
Roger J. Thompson
Robert E. Campbell

A photocleavable protein (PhoCl) that spontaneously dissociates into two fragments after illumination with violet light expands the toolkit for cellular optogenetics.

Keywords:

Molecular biology
Violet light
Biology
Fluorescence-lifetime imaging microscopy
Protein design
Optogenetics
Biochemistry

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