Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency

Joe Eun Son,Zhengchao Dou,Siyi Wanggou,Jade Chan,Rong Mo,Xuejun Li,Xi Huang,Kyoung-Han Kim,Jacques L. Michaud,Chi Chung Hui

Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency

2021

Joe Eun Son
Zhengchao Dou
Siyi Wanggou
Jade Chan
Rong Mo
Xuejun Li
Xi Huang
Kyoung-Han Kim
Jacques L. Michaud
Chi Chung Hui

The paraventricular nucleus of the hypothalamus (PVH) contains a heterogeneous cluster of Sim1-expressing neurons critical for feeding regulation. Sim1 haploinsufficiency results in hyperphagic obe...

Keywords:

Ectopic expression
Nucleus
Haploinsufficiency
SIM1
Biology
Hypothalamus
Cell biology

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