Synthesis, structural characterization and antitumoral activity of (NH4)4Li2V10O28.10H2O compound

Abstract The decavanadate compound with inorganic cations, (NH4)4Li2V10O28.10H2O, was synthesized by slow evaporation from aqueous solution. It was characterized by Infrared (IR) spectroscopy, Scanning Electron Microscopy (SEM) with Energy Dispersive X-Ray Analysis (EDX) as well as thermal analysis such as Differential Scanning Calorimetry (DSC), differential thermal analysis (DTA) and thermogravimetry (TG). The formula unit consists of one decavanadate cluster [V10O28]6−, two lithium cations, four ammonium ions and ten water molecules. In the crystal, molecules are linked into a three-dimensional network by O-H…O and N-H…O hydrogen bonds. The prevalence of these intermolecular interactions was confirmed by an analysis of the Hirshfeld surface (HS) and fingerprint plots (FP). The relative contribution of different interactions to the HS indicates that the O…H/H…O and H…H contacts account 86.8% of the total HS area. In this study, the cytotoxic and the antiproliferative activities of (NH4)4Li2V10O28.10H2O on human cancer cells (U87, IGR39 and MDA-MB-231) were investigated. This compound demonstrated dose-dependent antiproliferative activity on U87, MDA-MB-231 and IGR39 with IC50 values of 2 µg/mL, 18 µg/mL and 12 µg /mL, respectively. These data provide evidence on the potential anticancer activity of (NH4)4Li2V10O28.10H2O.