Periodicity and dosage optimization of an RNAi model in eukaryotes cells

Background As a highly efficient and specific gene regulation technology, RNAi has broad application fields and good prospects. The effect of RNAi enhances as the dosage of siRNA increases, while an exorbitant siRNA dosage will inhibit the RNAi effect. So it is crucial to formulate a dose-effect model to describe the degradation effects of the target mRNA at different siRNA dosages.