Periodontal diseaseandhemolysisinglucose-6-phosphatedehydrogenasedeficiency:Isthereanexus?
2019
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect
that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive
oxygen species. Consequently, erythrocyte destruction and hemolysis occur.
Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD
deficient individuals induced by periodontal infection is highlighted.
Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may
increase the risk of hemolysis in individuals with G6PD deficiency.
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