Increased extrafollicular expression of the B-cell stimulatory molecule CD70 in HIV-1-infected individuals

Objective:CD70 molecules expressed by activated T cells provide potent B cell stimulatory signals. We hypothesized that an altered CD70 expression might contribute to B cell abnormalities during HIV-1 infection.Design:CD70 expression and the functional and migratory properties of the CD4+CD70+ T lym