Development of in vivo fiber-optic Raman spectroscopy system with a miniaturized endoscope: demonstrations at the rat gastroesophageal epithelia

In vivo measurements of Raman spectra have been performed at the gastroesophageal epithelia of living rats by combining fiber-optic Raman spectroscopy system with an available endoscope unit for experimental animals. In our system, the endoscope worked well for a navigator with a probe channel, imaging and lighting fibers. Demonstrating in vivo Raman spectroscopy at the epithelia, the performance of our system was evaluated.