Furanoeremophilanes and a bakkenolide from Senecio auricula var. major

Abstract The roots of Senecio auricula var. major yielded, in addition to known compounds, four new eremophilane derivatives: the furanoeremophilanes 6 β -(2-methylbutyryloxy)-10 αH -furanoeremophilan-1-one, 6β-isobutyryloxysenberginone, 6β-(2-methylbutyryloxy)-senberginone and the bakkenolide 11 β ,12 β -epoxy-6β-(2-methylbutyryloxy)- Δ 1(10) -7-epidihydrobakkenolide A (senauricolide). Alkaline hydrolysis of senberginone esters gave, apart from the expected alcohols, the isomeric new 1 β -hydroxy-10 βH -furanoremophilan-6-one. The aerial parts contained α-tocopherol, fatty esters of β-amyrin, fatty esters of 20(29)-lupene-3β,16β-diol and sitosterol.