Independent Consumption of High and Low Molecular Weight Kininogens in Vivo

The levels of high molecular weight (HMW) kininogen and pre-kallikrein in rat plasma were markedly reduced after single injection of bromelian (10 mg/kg, i. v.) and gradually recovered over a 72 hour period. The level of low molecular weight (LMW) kininogen, however, was not changed during this period.