Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with anti-apoptotic effects on the pancreatic beta cell. The aim of this study was to generate transgenic mice with fluorescently labelled GIP-secreting K cells and to use these to investigate pathways by which K cells detect nutrients.