Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between Populations as a Confounding Factor in Association Studies

Luis Alberto Henríquez-Hernández,A. Valenciano,Palmira Foro-Arnalot,Maria Jesus Alvarez-Cubero,Jose Manuel Cozar,José Francisco Suárez-Novo,Manel Castells-Esteve,Adriana Ayala-Gil,Pablo Fernández-Gonzalo,Montse Ferrer,Ferran Guedea,Gemma Sancho Pardo,Jordi Craven-Bartle,Mariá José Ortiz Gordillo,Patricia Cabrera-Roldán,Estefanía Herrera-Ramos,P.C. Lara

Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between Populations as a Confounding Factor in Association Studies

2013

Luis Alberto Henríquez-Hernández
A. Valenciano
Palmira Foro-Arnalot
Maria Jesus Alvarez-Cubero
Jose Manuel Cozar
José Francisco Suárez-Novo
Manel Castells-Esteve
Adriana Ayala-Gil
Pablo Fernández-Gonzalo
Montse Ferrer
Ferran Guedea
Gemma Sancho Pardo
Jordi Craven-Bartle
Mariá José Ortiz Gordillo
Patricia Cabrera-Roldán
Estefanía Herrera-Ramos
P.C. Lara

Background: Differences in the distribution of genotypes between individuals of the same ethnicity are an important confounder factor commonly undervalued in typical association studies conducted in radiogenomics.

Keywords:

Cohort
Genetic association
Haplotype
Genetic heterogeneity
Cohort study
Confounding Factors (Epidemiology)
Confounding
Radiogenomics
Bioinformatics
Biology
Genotyping
Allele frequency
Population
SNP genotyping
Genetics
Single-nucleotide polymorphism

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