Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

Brian J. Groendyke,Behnam Nabet,Mikaela L. Mohardt,Haisheng Zhang,Ke Peng,Eriko Koide,Calvin R. Coffey,Jianwei Che,David A. Scott,Adam J. Bass,Nathanael S. Gray

Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

2020

Brian J. Groendyke
Behnam Nabet
Mikaela L. Mohardt
Haisheng Zhang
Ke Peng
Eriko Koide
Calvin R. Coffey
Jianwei Che
David A. Scott
Adam J. Bass
Nathanael S. Gray

Focal adhesion kinase (FAK) is a tyrosine kinase with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival and is an attractive target for the de...

Keywords:

Focal adhesion
Angiogenesis
Aminothiazole
Chemistry
Cell biology
cell survival
Tyrosine kinase

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