Disposition of Choline for the Brain

Choline keeps a crucial position in the metabolism and in the function of mammalian brain because it is a cornerstone for the synthesis of both acetylcholine, one of the most significant transmitters in the brain, and phosphatidylcholine, one of the backbones in biological membranes. The concentration of choline, which in rat brain is not higher than 28 nmol/g, is amazingly low and the turnover time of 45 sec is very high at least in comparison with the very large amount of 20,000 nmol/g of choline containing phospholipids with a turnover time of 17 hrs and also with regard to the very high turnover of acetylcholine depending on functional demands.