Grafted antibody compositions and methods cytokine for use in immunoregulation

The present disclosure provides antibody compositions grafted cytokine, including, for example, grafted constructs bind to stimulate intracellular signaling through a member of the super-family interleukin receptor (i.e., lL10R1), and stimulate signaling. Find use in compositions provided improved anti-inflammatory responses of cells, and relatively reduce the proinflammatory effects in the treatment, amelioration and prevention of related immune system can be countered with increased anti-inflammatory response disorders. Additionally, polynucleotides and vectors encoding such molecules, and host cells capable of producing molecules, as well as methods of making and using compositions are provided.