Atorvastatin amino acid and preparation method thereof

2011 
The invention relates to an atorvastatin amino acid and a preparation method thereof. Atorvastatin acid reacts with alkaline amino acid to obtain the compound. The preparation method comprises the following steps: (1) weighing the atorvastatin acid, and dissolving the atorvastatin acid into C1-C6 alcohol solvents, water or chlorinated hydrocarbon solvent to form a solution A; (2) weighing the alkaline amino acid, and dissolving the alkaline amino acid into C1-C6 alcohol solvents or water to form a solution B; and (3) adding the solution B into the solution A, enabling the mixed solution to beclear, separating out crystals from a mother solution, i.e., the atorvastatin amino acid. The atorvastatin amino acid prepared by the invention not only has the effect of treating hypercholesterolemia and combined hyperlipidemia, but also additionally has the functions of amino acid, for example, arginine has a protection function on liver, and therefore, the salt provided by the invention effectively makes up the defect that the known calcium salt, kali salt, sodium salt and the like have the side effect of damage to liver.
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