The Aza-Wharton Reaction: Syntheses of Cyclic Allylic Amines and Vicinal Hydroxyamines from the Respective Acylaziridines

The Wharton reaction, initially described for acyl epoxides, has been studied using the structurally similar aziridines. By this reaction, a range of cyclic allylic amines and vicinal amino alcohols have been prepared stereoselectively and, in some cases, enantiomerically pure.