Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro

AIM: To study the effect of 10-hydroxy-2-decenoic acid (HDA) on the macrophages activity of rats in vitro. METHODS: To measure the effects of HDA on phagocytosis, the production of antitumor cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) in vitro. RESULTS: HDA 50, 100 mg.L-1 promoted phagocytic activity from 0.353 +/- 0.017 to 0.39 +/- 0.04 and 0.382 +/- 0.017 A, increased TNF and IL-1 production from 0.23 +/- 0.07% to 0.43 +/- 0.04%, 0.47 +/- 0.04% and from 2384 +/- 180 to 2943 +/- 295, 3825 +/- 450 dpm, respectively. CONCLUSION: The upregulating effects of HDA on phagocytosis of PMO and production of TNF, IL-1 contribute to the host antitumor and immunomodulating mechanism.