The anti-tumor effect of murine IL-4 tumor cells transfected with both of B7 and IL-6 gene

When mice were immunized with the above irradiated EL-4 transfectant cells and challenged 7 days later with parental EL-4 cells, the survival time of mice was significantly prolonged. However, there is no difference between the survival time of mice vaccination with EL-4 cells transfected with double IL-6+B7 genes and single IL-6 or B7 gene.