Novel Cocrystals and Eutectics of the Antiprotozoal Tinidazole: Mechanochemical Synthesis, Cocrystallization, and Characterization

Octavio E. Fandiño,Lucía Reviglio,Yamila Garro Linck,Gustavo A. Monti,Marina M. Marcos Valdez,Sonia N. Faudone,Mino R. Caira,Norma R. Sperandeo

Novel Cocrystals and Eutectics of the Antiprotozoal Tinidazole: Mechanochemical Synthesis, Cocrystallization, and Characterization

2020

Octavio E. Fandiño
Lucía Reviglio
Yamila Garro Linck
Gustavo A. Monti
Marina M. Marcos Valdez
Sonia N. Faudone
Mino R. Caira
Norma R. Sperandeo

Antiprotozoal tinidazole (TNZ) exhibits low aqueous solubility (Sw) and poor photochemical stability. In this work, TNZ was used to form cocrystals and eutectics with the aim of enhancing its solub...

Keywords:

Eutectic system
aqueous solubility
Inorganic chemistry
Antiprotozoal
Chemistry
Tinidazole
Combinatorial chemistry

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