Chiral self-assembly of a novel (CuII/ReVII)-heterobimetallic l-Arginine complex: Crystal structure, Hirshfeld surface analysis, spectroscopic properties and biochemical studies

Abstract A novel (Cu II /Re VII )-heterobimetallic complex based on l -Arginine, namely trans -[Cu( l -Arg) 2 (ReO 4 ) 2 ] (CuLARe), was successfully synthesized and fully characterized using X-ray structure analysis as well as (IR/UV–vis) spectroscopy, molar conductivity and (TG/DTA) thermal methods. The crystal structure determination reveals that CuLARe has a non-symmetrical atomic arrangement and features striking helical chains of {[Cu( l -Arg) 2 (ReO 4 ) 2 ]} n , which are further assembled into a 3D-supramolecular network through multidirectional N(C, O)-H⋯O hydrogen bonding interactions. Analysis by Hirshfeld surface generation in combination with 2D-fingerprinting was also performed to elucidate the nature of the interactions and their contributions towards the crystal packing. Moreover, a comparative antioxidant screening of CuLARe with the free ligands as well as CuCl 2 has been investigated. The results emphasize that the complexation of ligands to the metal ions plays a crucial role in the improvement of the biochemical properties of CuLARe.